2-Pyrrolidinone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

2-Pyrrolidinone 是 γ-氨基丁酸 (GABA) 的内酰胺环化产物。氨己烯酸（VGB，一种抗癫痫药）会增加人脑中的γ-氨基丁酸（GABA）和相关代谢物，包括 2-吡咯烷酮。

2-Pyrrolidinone is a lactam cyclization product of gamma-aminobutyric acid (GABA). Vigabatrin (VGB an antiepileptic drug) increases human brain gamma-aminobutyric acid (GABA) and the related metabolites including 2-pyrrolidinone.

Radical scavenging activity increases with increasing the amount of 2-Pyrrolidinone. The cytotoxicity of 2-Pyrrolidinone is found to be dose and time dependent, and the effect is observed microscopically in all of the selected cancer cell lines. It is observed that 2-Pyrrolidinone has cytotoxic concentrations of 2.5 mg/mL for HeLa, 3 mg/mL for PC-3 cells at 24 h and 1.5 mg/mL for HeLa and 2 mg/mL for PC-3 cells at 48 h, respectively. The cell viability decreases with increasing concentrations of puri?ed 2-Pyrrolidinone.After treatment with 2-Pyrrolidinone their IC50 concentrations (1.5 mg/mL and 2 mg/mL for HeLa and PC-3 cells, respectively) for a period of 24 h, morphological changes in the cells are observed. It is demonstrated that 2-Pyrrolidinone induces apoptosis in HeLa and PC-3 cells via G0/G1phase of cell cycle arrest.

——

Butyrolactam | 2-Ketopyrrolidine | 2-Oxopyrrolidine

Others

Other Targets

Others

——

——

616-45-5

85.1

C4H7NO

>98% (HPLC)

DMSO:10 mM

O=C1CCCN1

——

(-20℃)

With Ice Pack

≥ 2 years