CA-5f

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CA-5f 是一种有效的晚期巨自噬/自噬抑制剂，通过抑制自噬体-溶酶体融合。

CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.

Cell Viability Assay Cell Line:A549, HUVECs Concentration:20 μM Incubation Time:96 hours Result:Exhibited more cytotoxicity against A549 cells compared with normal HUVECs.Western Blot Analysis Cell Line:A549 cells and HUVECs Concentration:0-40 μM Incubation Time:6 hours Result:Elevated LC3B-II (a marker to monitor autophagy) and SQSTM1 protein levels in a concentration- and time-dependent manner.

Animal Model:Nude mice bearing A549 lung cancer cellsDosage:40 mg/kg Administration:Injected via caudal vein, every 2 days for up to 30 days Result:Significantly suppressed tumor volume and weight in mice, increased the number of apoptotic cells in mice.

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Autophagy

Autophagy

Autophagy

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1370032-19-1

388.46

C24H24N2O3

>98% (HPLC)

DMSO: 70 mg/mL;Water: Insoluble

COc1ccc(\C=C2/CN(C)C\C(=C/c3c[nH]c4ccccc34)C2=O)cc1OC

(3E5E)-3-(34-dimethoxybenzylidene)-5-[(1H-indol-3-yl)methylene]-1-methylpiperidin-4-one

(-20℃)

With Ice Pack

≥ 2 years