Juglone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

胡桃醌是一种天然萘醌，存在于黑胡桃 (J. nigra) 和胡桃科其他植物中。 Juglone 还不可逆地抑制小病毒蛋白家族的肽基-脯氨酰顺/反异构酶，包括人 Pin1、酵母 Ess1/Ptf1 和大肠杆菌小病毒蛋白 (Ki = 55.9 nM)。

Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family including human Pin1 yeast Ess1/Ptf1 and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I II and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction both through Pin1-independent mechanisms.

Cell Cytotoxicity Assay Cell Line:SGC-7901 Concentration:5, 10, 15, 20 μM Incubation Time:24 h Result:Inhibited cell growth in a dose-dependent manner.Apoptosis Analysis Cell Line:SGC-7901 Concentration:5, 10, 15, 20 μM Incubation Time:24 h Result:Increased the number of early apoptotic cells.Western Blot Analysis Cell Line:SGC-7901 Concentration:5, 10, 15, 20 μM Incubation Time:24 h Result:Decreased the expression of Bcl-2 and increased the Bax protein.

Animal Model:High-fat diet rats modelDosage:0.25 or 1 mg/kg Administration:p.o.Result:Regulated the expression of s TNF-α, IL-1β and IL-6.Inhibited the TLR4 expression and NF-kappa activity.

Regianin | 5-Hydroxy-14-naphthoquinone

Cell Cycle/DNA Damage

DNA/RNA Synthesis

RNA polymerase

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481-39-0

174.15

C10H6O3

>98% (HPLC)

DMSO: 15 mg/mL;Ethanol: 15 mg/mL

Oc1cccc2C(=O)C=CC(=O)c12

5-hydroxynaphthalene-14-dione

(-20℃)

With Ice Pack

≥ 2 years