α-Ketoglutaric acid sodium salt ( 2-oxoglutarate monobasic | Oxoglutaric acid | AKG )

产品货号. M19760 CAS No. 22202-68-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

α-Ketoglutaric acid sodium salt
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

α-酮戊二酸是 TCA 循环中的关键分子。它可以由谷氨酸通过谷氨酸脱氢酶氧化脱氨产生，并且是磷酸吡哆醛依赖性转氨反应（由支链氨基酸转氨酶介导）的产物，其中谷氨酸是常见的氨基供体。
产品描述

alpha-Ketoglutarate is a key molecule in the TCA cycle(PMID: 26759695 ). It can be produced from glutamate by oxidative deamination via glutamate dehydrogenase and as a product of pyridoxal phosphate-dependent transamination reactions (mediated by branched-chain amino acid transaminases) in which glutamate is a common amino donor.
体外实验

2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) has other physiological capabilities including reduction of ammonia level formed in the lung and general ammonia detoxification, protective role against lipid peroxidation and neuroprotective effect against cyanide poisoning.2-Ketoglutaric acid Sodium acts as precursor for the synthesis of amino acids and nucleotides.
体内实验

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同义词

2-oxoglutarate monobasic | Oxoglutaric acid | AKG
通路

Others
靶点

Other Targets
受体

Others
研究领域

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适应症

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1.Wu N et al. Alpha-Ketoglutarate: Physiological Functions and Applications. Biomol Ther (Seoul). 2016 Jan;24(1):1-8.

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