Sodium taurolithocholate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

主要人类代谢物，一种胆汁酸，可抑制放射性配体与毒蕈碱 M1 受体的结合，但不与 M2 或 M3 受体结合。

The major human metabolite a bile acid which inhibits radioligand binding to muscarinic M1 but not to M2 or M3 receptors.

Taurolithocholic acid (TLCA) at low concentrations (5 μM) tends to selectively increase the membrane-associated fraction of the e-isoform of PKC by 44.1% ± 40.2%.TLCA (10 μM) selectively induces translocation of theε-isoform of PKC to the hepatocellular membranes, a key step for activation of mobile PKC isoforms.

Taurolithocholic acid (TLCA) exerts cholestatic effects via PI3K-dependent mechanisms in perfused rat Livers and rat hepatocyte couplets.

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Others

Other Targets

Others

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6042-32-6

505.69

C26H44NNaO5S

>98% (HPLC)

DMSO: 20 mg/mL

[Na+].C[C@H](CCC(=O)NCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

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(-20℃)

With Ice Pack

≥ 2 years