Rotundine b

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Rotundine (L-tetraHydropalmatine, L-THP) 是一种选择性多巴胺 D1 受体拮抗剂，IC50 为 166 nM。

Rotundine (L-tetrahydropalmatine L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.(In Vivo):It is reported that Rotundine (l-THP) possesses a blocking effect on dopamine D1 and D2 receptors and can inhibit physical dependence in morphine dependent mice and significantly reduce the development of the conditional place preference induced by morphine in mice. On day 1 and 7, there is no difference in locomotor counts between the Rotundine groups (6.25, 12.5, and 18.75 mg/kg) and saline group [F(3, 37)=1.360, P>0.05, F(3, 37)=0.348, P>0.05, respectively]. Locomotor counts are greatly increased in the oxycodone group compare with the saline group. Rotundine at doses of 6.25, 12.5, and 18.75 mg/kg antagonizes hyperactivity induced by oxycodone [F(4, 60)=15.76, P<0.01]. Rotundine (6.25, 12.5 mg/kg) does not affect the magnitude of sensitization, but there is a marked difference between oxycodone+oxycodone group and Rotundine (18.75 mg/kg)+oxycodone+oxycodone group, indicating that Rotundine (18.75 mg/kg) greatly inhibits the development of oxycodone sensitization [F(4, 62)=8.766, P<0.01].

——

It is reported that Rotundine (l-THP) possesses a blocking effect on dopamine D1 and D2 receptors and can inhibit physical dependence in morphine dependent mice and significantly reduce the development of the conditional place preference induced by morphine in mice. On day 1 and 7, there is no difference in locomotor counts between the Rotundine groups (6.25, 12.5, and 18.75 mg/kg) and saline group [F(3, 37)=1.360, P>0.05, F(3, 37)=0.348, P>0.05, respectively]. Locomotor counts are greatly increased in the oxycodone group compare with the saline group. Rotundine at doses of 6.25, 12.5, and 18.75 mg/kg antagonizes hyperactivity induced by oxycodone [F(4, 60)=15.76, P<0.01]. Rotundine (6.25, 12.5 mg/kg) does not affect the magnitude of sensitization, but there is a marked difference between oxycodone+oxycodone group and Rotundine (18.75 mg/kg)+oxycodone+oxycodone group, indicating that Rotundine (18.75 mg/kg) greatly inhibits the development of oxycodone sensitization [F(4, 62)=8.766, P<0.01].

L-Tetrahydropalmatine | (-)-Tetrahydropalmatine | Caseanine | Gindarine

GPCR/G Protein

Dopamine Receptor

D1 receptor 5-HT1A D2 receptor D3 receptor

——

——

483-14-7

355.43

C21H25NO4

>98% (HPLC)

DMSO:8 mg/mL (22.5 mM);Ethanol:<1 mg/mL;Water:<1 mg/mL

[H][C@@]12CC3=CC=C(OC)C(OC)=C3CN1CCC1=C2C=C(OC)C(OC)=C1

——

(-20℃)

With Ice Pack

≥ 2 years