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Deltonin
CAS No. 55659-75-1
Deltonin ( —— )
产品货号. M19433 CAS No. 55659-75-1
Deltonin 具有抑制 ERK1/2 和 AKT 激活的作用。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2841 | 有现货 |
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| 10MG | ￥4161 | 有现货 |
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| 25MG | ￥6389 | 有现货 |
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| 50MG | ￥8789 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥4237 | 有现货 |
|
生物学信息
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产品名称Deltonin
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Deltonin 具有抑制 ERK1/2 和 AKT 激活的作用。
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产品描述Deltonin has an inhibition of ERK1/2 and AKT activation. Deltonin shows cytotoxicity against human HepG2 cells (IC50: 7.66 μM) mouse C26 cells (IC50: 1.22 μM) and human MDA-MB-231 cells (IC50: 1.58 μM).
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体外实验Deltonin inhibits ERK1/2 and AKT activation. Deltonin (0.5-8 μM) significantly inhibits the proliferation of several colon cancer cell lines including SW480, SW620, LOVO and C26, with IC50s of 1.3, 1.29, 2.11 and 1.22 μM. Deltonin also causes G2-M phase arrest and induces apoptosis in C26 cells.Deltonin (0-5 μM) decreases the phosphorylation of AKT and ERK1/2 levels in MDA-MB-231 cells. Deltonin (0.5-8 μM) also dose-dependently inhibits the proliferation, and causes apoptosis with ROS production in MDA-MB-231 cells.
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体内实验Deltonin (20 and 40 mg/kg, p.o.) reduces the tumor growth of 37.7% and 56.7%, and causes a 50-day survival rate of 60% and 50%, respectively, in mice. Deltonin also inhibits tumor angiogenesis in mice.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number55659-75-1
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分子量885.05
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分子式C45H72O17
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纯度>98% (HPLC)
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溶解度Water
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SMILESO[C@@H]9[C@H](O)[C@@H](O)[C@H](C)O[C@H]9O[C@@H]8[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@@H](CO)O[C@H]8O[C@@H]6CC7=CC[C@@H]3[C@H](CC[C@]4(C)[C@H]5[C@H](C)[C@@]2(CC[C@@H](C)CO2)O[C@H]5C[C@@H]34)[C@@]7(C)CC6
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Tong QY et al. Deltonin a steroidal saponin inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and antiangiogenesis. Cell Physiol Biochem. 2011;27(3-4):233-42.
