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HC-067047
CAS No. 883031-03-6
HC-067047 ( HC-067047 | HC 067047 | HC067047 )
产品货号. M19226 CAS No. 883031-03-6
HC-067047 是一种有效的选择性 TRPV4 拮抗剂。还抑制内源性 TRPV4 介导的对 4α-PDH 的反应。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥520 | 有现货 |
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| 10MG | ￥867 | 有现货 |
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| 25MG | ￥1748 | 有现货 |
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| 50MG | ￥2688 | 有现货 |
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| 100MG | ￥3798 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥540 | 有现货 |
|
生物学信息
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产品名称HC-067047
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述HC-067047 是一种有效的选择性 TRPV4 拮抗剂。还抑制内源性 TRPV4 介导的对 4α-PDH 的反应。
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产品描述HC-067047 is a potent and selective TRPV4 antagonist. HC-067047 increases functional bladder capacity and reduces micturition frequency in WT mice and rats with cystitis. HC-067047 did not affect bladder function in Trpv4(-/-) mice, demonstrating that its in vivo effects are on target. HC-067047 may provide a promising means of treating bladder
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体外实验HC-067047 (1 μM; 24 hours; HEI-OC1 cells) treatment significantly decreases mRNA expression in high glucose cultured HEI-OC1 cells.?HC-067047 (1 μM; 24 hours; HEI-OC1 cells) treatment significantly decreases the expression of TRPV4 protein.HC-067047 (1 μM; 48 hours; HEI-OC1 cells) treatment inhibits cell proliferation.HC-067047 (1 μM; 48 hours; HEI-OC1 cells) treatment promotes cell apoptosis. RT-PCR Cell Line:HEI-OC1 cells Concentration:1 μM Incubation Time:24 hours Result:The mRNA expression was significantly decreased.Western Blot Analysis Cell Line:HEI-OC1 cells Concentration:1 μM Incubation Time:24 hours Result:The expression of TRPV4 protein was significantly decreased.Cell Proliferation Assay Cell Line:HEI-OC1 cells Concentration:1 μM Incubation Time:48 hours Result:Inhibited cell proliferation.Apoptosis Analysis Cell Line:HEI-OC1 cells Concentration:1 μM Incubation Time:48 hoursResult:Promoted cell apoptosis.
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体内实验Animal Model:Cyclophosphamide-treated WT and Trpv4?/? mice, and naive WT miceDosage:0 mg/kg, 1 mg/kg, 10 mg/kg, 50 mg/kg Administration:Intraperitoneal injection; for 30 minutes Result:Increased functional bladder capacity and reduces micturition frequency in WT mice with cystitis and did not affect bladder function in Trpv4?/? mice.
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同义词HC-067047 | HC 067047 | HC067047
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通路Others
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靶点Other Targets
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受体hTRPV4/mTRPV4
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研究领域Cancer
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适应症——
化学信息
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CAS Number883031-03-6
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分子量471.51
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分子式C26H28F3N3O2
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纯度>98% (HPLC)
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溶解度DMSO : 50 mg/mL 106.04 mM
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SMILESFC(F)(F)c1cc(ccc1)NC(=O)c4cc(c2ccccc2)n(CCCN3CCOCC3)c4C
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化学全称2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Everaerts W et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19084-9.
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