Mildronate dihydrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

米屈膦酸二水合物是一种通过 γ-丁甜菜碱 (GBB) 羟化酶生物合成左旋肉碱的抑制剂，也是肾肉碱重吸收的竞争性抑制剂。

Mildronate dihydrate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.

RT-PCRCell Line:Rat alveolar type II epithelial RLE-6TN cells in hypoxia incubator Concentration:20, or 40 μM Incubation Time:24 h Result:Significantly decreased the mRNA expression of PFKP, PDK1, and PKM2 compared with the hypoxia group.Western Blot Analysis Cell Line:Rat alveolar type II epithelial RLE-6TN cells in hypoxia incubator Concentration:20, or 40 μM Incubation Time:24 h Result:Significantly reduced the protein expression of PFKP, PKM2, and LDHA.

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Others

Antioxidant

GBB hydroxylase

Cardiovascular Disease

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86426-17-7

147.19

C6H14N2O2

>98% (HPLC)

In Vitro:?H2O : 100 mg/mL (548.79 mM)

C[N+](C)(C)NCCC(=O)[O-].O.O

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(-20℃)

With Ice Pack

≥ 2 years