Enalapril Maleate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

马来酸依那普利是一种血管紧张素转换酶 (ACE) 抑制剂，用于治疗高血压、慢性心力衰竭和糖尿病肾病。

Enalapril Maleate, an angiotensin-converting enzyme (ACE) inhibitor, is utilized in the treatment of hypertension, chronic heart failure , and diabetic nephropathy.(In Vivo):Enalapril (MK-421) is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to enalaprilat following oral administration. Enalapril (MK-421) is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Enalapril may be used to treat essential or renovascular hypertension and symptomatic congestive heart failure.

——

Enalapril (MK-421) is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to enalaprilat following oral administration. Enalapril (MK-421) is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Enalapril may be used to treat essential or renovascular hypertension and symptomatic congestive heart failure.

MK-421 (maleate)

Proteasome/Ubiquitin

Endogenous Metabolite

ACE

Cardiovascular Disease

——

76095-16-4

492.52

C20H28N2O5·C4H4O4

>98% (HPLC)

DMSO : ≥ 50 mg/mL 101.52 mM H2O : 33.33 mg/mL67.67 mM

OC(=O)/C=C\C(=O)O.N1(C(=O)[C@@H](N[C@H](C(=O)OCC)CCc2ccccc2)C)[C@H](C(=O)O)CCC1

——

(-20℃)

With Ice Pack

≥ 2 years