Pseudoginsenoside F11

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Pseudoginsenoside-F11 是西洋参的成分，可对抗东莨菪碱、吗啡、甲基苯丙胺引起的小鼠学习记忆缺陷。

Pseudoginsenoside-F11 is a component of Panax quinquefolium (American ginseng), can antagonize the learning and memory deficits induced by scopolamine, morphine, and methamphetamine in mice.

Biochemical experiments revealed that Pseudoginsenoside F11 (Ginsenoside A1) could inhibit diprenorphine (DIP) binding with an IC50 of6.1 μM and reduced the binding potency of morphine in Chinese hamster ovary (CHO)-μ cells.

One in vivo model of cisplatin-induced acute renal failure was performed. The results showed that pretreatment with Pseudoginsenoside Pseudoginsenoside F11 (Ginsenoside A1) reduced cisplatin-elevated blood urea nitrogen and creatinine levels, as well as ameliorated the histophathological damage . We tested the effects of Pseudoginsenoside Pseudoginsenoside F11 (Ginsenoside A1) on morphine-induced development of behavioral sensitization and alterations in glutamate levels in the medial prefrontal cortex (mPFC) in freely moving mice by using in vivo microdialysis. As the results shown, Pseudoginsenoside Pseudoginsenoside F11 (Ginsenoside A1) antagonized the development of behavioral sensitization and decrease of glutamate in the mPFC induced by morphine.

Ginsenoside A1

Others

Other Targets

Others

Others-Field

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69884-00-0

801.01

C42H72O14

>98% (HPLC)

DMSO : 100 mg/mL 124.84 mM; H2O : 0.67 mg/mL 0.84 mM

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(-20℃)

With Ice Pack

≥ 2 years