Aurantio-obtusin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Aurantio-obtusin 是一种有前途的天然来源的骨合成代谢化合物，在预防骨质疏松症和其他代谢性骨疾病方面具有潜在的治疗应用。

Biotransformation of glucoAurantio-obtusin towards Aurantio-obtusin increased the toxicity of irinotecan through increased inhibition of SN-38 glucuronidation. Aurantio-obtusin, stimulated chemotactic migration of MC3T3-E1 osteoblast cells in a concentration-dependent manner. Besides migration, the compound stimulated osteoblast differentiation and mineralization. Aurantio-obtusin is a promising osteoanabolic compound of natural origin with potential therapeutic applications in the prevention of osteoporosis and other metabolic bone diseases.

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Animal Model:C57BL/6J mice model Dosage:5 mg/kg, 10 mg/kg, 15 mg/kg Administration:Oral gavage (p.o.), feeding with HFSW diet for 4 weeks then giving different dose of Aurantio-obtusin for another 4 weeks. Result:Decreased the levels of TG and TC in liver and TG, ALT and AST in serum induced by HSFW.Reduced the number and size of fat droplets in liver cells.Significantly increased AMPK phosphorylation in HFSW-induced mice.

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Others

Other Targets

Others

Others-Field

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67979-25-3

330.29

C17H14O7

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (75.69 mM)

CC1=C(C(=C2C(=C1)C(=O)C3=CC(=C(C(=C3C2=O)O)OC)O)OC)O

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(-20℃)

With Ice Pack

≥ 2 years