Chicoric Acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Chicoric Acid 是人类免疫缺陷病毒 1 型 (HIV-1) 整合酶和组织复制的有效抑制剂。

Chicoric Acid is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetics with CB2 receptor-dependent and independent.

Cell Viability Assay Cell Line:3T3-L1 preadipocytes Concentration:10-200 μM Incubation Time:24, 48, and 72 hours Result:Had no effect on the viability of 3T3-L1 preadipocytes with 10-50 μM for 24 h, but significantly decreased cell viability with 100 μM and 200 μM.Apoptosis Analysis Cell Line:3T3-L1 preadipocytes Concentration:100 μM Incubation Time:48 hours Result:Demonstrated typical characteristics of apoptosis such as cell shrinkage, chromatin condensation, and the increased permeability of cell membranes after DAPI and AO/EB staining.Western Blot Analysis Cell Line:3T3-L1 preadipocytes Concentration:100 μM Incubation Time:48 hours Result:Decreased the protein level of p-Akt in a dose- and time-dependent manner.

Animal Model:C57BL/6J mice with STZ (50 mg/kg; ip; for consecutive 5 days)Dosage:60 mg/kg Administration:Drinking water; daily; for 4 weeks Result:Inhibited pancreas apoptosis and adjusted islet function in diabetic mice, leading to an increase in insulin generation and secretion. Regulated mitochondrial biogenesis, glycogen synthesis, and inhibited inflammation via activating antioxidant responses. Showed a remarkable increase in body weight starting at week 7.

Cichoric acid | Dicaffeoyltartaric acid

GPCR/G Protein

Antibacterial

HIV-I integrase

Others-Field

——

6537-80-0

474.37

C22H18O12

>98% (HPLC)

DMSO : ≥ 347 mg/mL; 731.50 mM

OC(=O)[C@H](OC(=O)\C=C\c1ccc(O)c(O)c1)[C@@H](OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O

——

(-20℃)

With Ice Pack

≥ 2 years