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Cefoperazone
CAS No. 62893-19-0
Cefoperazone ( Cefobid | Cefozon | T1551 | T 1551 )
产品货号. M18925 CAS No. 62893-19-0
头孢哌酮与细菌细胞壁内膜上的青霉素结合蛋白 (PBP) 结合并使其失活。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | ￥178 | 有现货 |
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| 1G | ￥295 | 有现货 |
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| 1 mL x 10 mM in DMSO | ￥215 | 有现货 |
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生物学信息
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产品名称Cefoperazone
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述头孢哌酮与细菌细胞壁内膜上的青霉素结合蛋白 (PBP) 结合并使其失活。
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产品描述Cefoperazone binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. It can inhibit rMrp2-mediated [3H]E217βG uptake (IC50: 199 μM).
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体外实验——
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体内实验——
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同义词Cefobid | Cefozon | T1551 | T 1551
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通路Others
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靶点Other Targets
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受体Antibacterial
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研究领域Infection
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适应症——
化学信息
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CAS Number62893-19-0
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分子量645.67
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分子式C25H27N9O8S2
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 100 mg/mL 154.88 mM H2O : < 0.1 mg/mL
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SMILES[H][C@]12SCC(CSC3=NN=NN3C)=C(N1C(=O)[C@H]2NC(=O)[C@H](NC(=O)N1CCN(CC)C(=O)C1=O)C1=CC=C(O)C=C1)C(O)=O
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化学全称(6R,7R)-7-((R)-2-(4-ethyl-2,3-dioxopiperazine-1-carboxamido)-2-(4-hydroxyphenyl)acetamido)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Kato, Y., et al., Involvement of multidrug resistance-associated protein 2 (Abcc2) in molecular weight-dependent biliary excretion of beta-lactam antibiotics. Drug Metab Dispos, 2008. 36(6): p. 1088-96.
