Ursonic Acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

熊果酸属于熊果烷三萜家族，其结构基于五环熊果烷骨架。它具有作为 HIV-1 蛋白酶抑制剂的潜力。

Ursonic acid belongs to the family of Ursane Triterpenes whose structure is based on the pentacyclic ursane skeleton. It has potential as HIV-1 Protease Inhibitor.

Cell Proliferation Assay Cell Line:T24 human bladder cancer cells Concentration:12.5-50 μM Incubation Time:48 h Result:Inhibited cell proliferation in a dose-dependent manner.Western Blot Analysis Cell Line:T24 human bladder cancer cells Concentration:12.5-50 μM Incubation Time:48 h Result:Inhibited the anti-apoptotic signaling (pAkt1, pIκBα, NF-κBp65 and Bcl-2).

Animal Model:Adult male albino ratsDosage:5-20 mg/kg Administration:p.o., twice a day, 30 days Result:Increased weight gain and food intake.Decreased AST and ALT activities and total and indirect bilirubin levels.Increased direct bilirubin and levels of non-enzymic antioxidants (GSH, ascorbic acid and a-tocopherol).Decreased lipid peroxidation.

3-Ketoursolic acid

Others

Other Targets

Others

Others-Field

——

6246-46-4

454.69

C30H46O3

>98% (HPLC)

DMSO : 10 mg/mL 21.99 mM;

[C@H]1(CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]3[C@@]4(CCC(=O)C3(C)C)C)C)[C@@H]2[C@H]1C)C)C(=O)O)C

——

(-20℃)

With Ice Pack

≥ 2 years