Gabapentin HCl

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Gabapentin HCl 是一种 GABA 类似物，用于治疗癫痫和神经性疼痛。

Gabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain.(In Vitro):Gabapentin (0-300 μM) hydrochloride produces a concentration-dependent inhibition of the K+-induced [Ca2+]i increase in synaptosomes (IC50=14?μM; maximal inhibition by 36%). Gabapentin (100? μM) hydrochloride decreases the K+-evoked release of endogenous aspartate and glutamate in neocortical slices by 16 and 18%, respectively. Gabapentin (0-1000 μM) hydrochloride reduces the K+-evoked [3H]-noradrenaline release in neocortical slices (IC50=48?μM; maximal inhibition of 46%) but not from synaptosomes.(In Vivo):Gabapentin (5 and 10 mg/kg; i.p.; once; male BALB/c mice) hydrochloride has improving effects on spatial and emotional cognitive performance of naive mice in Morris water maze (MWM), passive avoidance (PA) and modified elevated plus maze (mEPM) tasks.Gabapentin (1-100 mg/kg; i.p.; once; male mice) hydrochloride has analgesic effect and reduces writhing in a dose-dependent manner.

Gabapentin (0-300 μM) hydrochloride produces a concentration-dependent inhibition of the K+-induced [Ca2+]i increase in synaptosomes (IC50=14?μM; maximal inhibition by 36%).Gabapentin (100? μM) hydrochloride decreases the K+-evoked release of endogenous aspartate and glutamate in neocortical slices by 16 and 18%, respectively.Gabapentin (0-1000 μM) hydrochloride reduces the K+-evoked [3H]-noradrenaline release in neocortical slices (IC50=48?μM; maximal inhibition of 46%) but not from synaptosomes.

Gabapentin (5 and 10 mg/kg; i.p.; once; male BALB/c mice) hydrochloride has improving effects on spatial and emotional cognitive performance of naive mice in Morris water maze (MWM), passive avoidance (PA) and modified elevated plus maze (mEPM) tasks.Gabapentin (1-100 mg/kg; i.p.; once; male mice) hydrochloride has analgesic effect and reduces writhing in a dose-dependent manner. Animal Model:Male BALB/c mice (35-45 g)Dosage:5 and 10 mg/kg Administration:Intraperitoneal injection; onceResult:Increased the time spent in target quadrant and decreased the distance to platform in MWM test.Decreased the transfer latency on second day in mEPM test.Prolonged retention latency in PA test.Animal Model:Male mice (26-30 g)Dosage:1, 5, 10, 50 and 100 mg/kg Administration:Intraperitoneal injection; once Result:Produced 45-70% inhibition of writhing.

——

Others

Other Targets

GABAR

Neurological Disease

——

60142-95-2

207.7

C9H17NO2·HCl

>98% (HPLC)

H2O : 50 mg/mL 240.73 mM;

Cl.NCC1(CC(O)=O)CCCCC1

——

(-20℃)

With Ice Pack

≥ 2 years