Cyclizine dihydrochloride ( —— )

产品货号. M18859 CAS No. 5897-18-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Cyclizine dihydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Cyclizine DiHClide 是一种组胺 H1 拮抗剂。它通过口服或肠胃外给药，用于控制术后和药物引起的呕吐以及晕动病。
产品描述

Cyclizine Dihydrochloride is a histamine H1 antagonist. It is given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness.
体外实验

Cyclizine (100 μM) dihydrochloride significantly inhibits nitrite accumulation and iNOS protein levels in the LPS-stimulated in RAW 264.7 cells supernatants.Cyclizine dihydrochloride inhibits anti-IgE-induced histamine release from isolated human lung fragments, with an IC50 of 5.42 μM.
体内实验

Cyclizine (1, 10 mg/kg) dihydrochloride enhances locomotor activity of mice in a dose-dependent manner. Animal Model:Naive male CDI mice (Charles River) weighing 25-30 g Dosage:1, 10 mg/kg Administration:s.c.; locomotor activity (crossings) measured every 15 min for 2 hr.Result:Enhanced locomotor activity in a dose-dependent manner.
同义词

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通路

Others
靶点

Other Targets
受体

H1 receptor
研究领域

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适应症

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1. Vella-Brincat JW, et al. J Pain Symptom Manage. 2012 Mar;43(3):540-8.

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