Sciadopitysin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

西亚多匹辛可以预防糖尿病骨病的发展，它通过上调线粒体生物合成发挥其治疗作用。

Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin shows protective effects on antimycin A-induced toxicity in osteoblastic MC3T3-E1 cells, it may reduce or prevent osteoblasts degeneration.Sciadopitysin can inhibit the Aβ aggregation and reduce Aβ-induced toxicity in the primary cortical neurons.

Sciadopitysin (2.5, 5, 10 μM ) strongly reduces RANKL-induced osteoclast-specific genes expression, including cathepsin K (CTSK), tartrate-resistant acid phosphatase (TRAP) and MMP-9. Furthermore, Sciadopitysin apparently attenuates RANKL-increased expressions of c-Fos and NFATc1.

Sciadopitysin (i.p.; 10 mg/kg; every other day for 8 days) can reverse the bone loss in LPS-induced mice model (C57BL/6 mice; 6 weeks old).

Sciadopitysin | NSC 45108 | NSC-45108 | NSC45108

Endocrinology/Hormones

Opioid Receptor

TNF-α

Others-Field

——

521-34-6

580.54

C33H24O10

>98% (HPLC)

In Vitro:?DMSO : 20 mg/mL (34.45 mM)

Oc1cc(OC)cc2OC(=CC(=O)c12)c6cc(c5c(O)cc(O)c3c5OC(=CC3=O)c4ccc(OC)cc4)c(OC)cc6

5,7-Dihydroxy-8-(5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl)-2-(4-methoxyphenyl)-4-benzopyrone

(-20℃)

With Ice Pack

≥ 2 years