Phloracetophenone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

2', 4', 6'-TriHydroxyacetophenone 具有抗肥胖和降血脂作用，可能部分是通过抑制胰腺脂肪酶活性来延迟肠道对膳食脂肪的吸收来介导的。

2', 4', 6'-Trihydroxyacetophenone has antiobesity and hypolipidemic effects, may be partly mediated by delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity.

Phloracetophenone (2,4,6-trihydroxyacetophenone) is a cholesterol-lowering agent, enhances cholesterol 7α-hydroxylase (CYP7A1) activity, and elevates CYP7A1 mRNA level.Phloracetophenone (1, 2, and 4 μmol/min) immediately and dose-dependently increases bile acid-independent bile flow in the isolated perfused rat liver.

Phloracetophenone (2,4,6-trihydroxyacetophenone; 125 or 250 μmol/kg, intraduodenal injection) shows choleretic activity requiring multidrug resistance protein-2 (Mrp2) in rats. Phloracetophenone (40 μmol/min) partially prevents the E2-17G induced cholestasis.

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Metabolic Enzyme/Protease

MMP

Others

Others-Field

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480-66-0

168.15

C8H8O4

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (148.68 mM)

CC(=O)c1c(cc(cc1O)O)O

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(-20℃)

With Ice Pack

≥ 2 years