021-51111890
购物车（）
sales@molnova.cn
SB366791
CAS No. 472981-92-3
SB366791 ( SB-366791 | SB 366791 | SB366791 )
产品货号. M18586 CAS No. 472981-92-3
SB-366791 是一种新型选择性肉桂酰胺 TRPV1 拮抗剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥236 | 有现货 |
|
| 10MG | ￥330 | 有现货 |
|
| 25MG | ￥686 | 有现货 |
|
| 50MG | ￥1097 | 有现货 |
|
| 100MG | ￥1773 | 有现货 |
|
| 200MG | ￥2592 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥253 | 有现货 |
|
生物学信息
-
产品名称SB366791
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述SB-366791 是一种新型选择性肉桂酰胺 TRPV1 拮抗剂。
-
产品描述SB-366791is a potent and selective TRPV1 antagonist. SB-366791 inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation. SB-366791 decreased capsaicin-induced Ca2+ influx in cultured trigeminal ganglion cells in a concentration-dependent manner (0.5-10 microM) with an IC50 of 651.9 nM. SB366791 is a more selective and in vivo also a more potent TRPV1 receptor antagonist than capsazepine in the rat therefore, it may promote the assessment of the therapeutic utility of TRPV1 channel blockers.
-
体外实验——
-
体内实验SB-366791 (30 μM) inhibits the frequency of miniature excitatory postsynaptic currents (EPSCs). SB-366791 (30 μM) reduces the frequency of spontaneous EPSCs in the spinal cord slices from FCA-treated rats. SB-366791(30 μM) inhibits the amplitude of C-fibre evoked EPSCs. SB-366791 has also been used in vivo to assess the potential analgesic action of the inhibition of TRPV1, and significantly inhibits capsaicin-induced hypothermia, eye wiping movements and vasodilatation in the knee joint. SB-366791 inhibits glutamatergic transmission via an apparently pre-synaptic mechanism(s).
-
同义词SB-366791 | SB 366791 | SB366791
-
通路Others
-
靶点Other Targets
-
受体TRPV1
-
研究领域Cancer
-
适应症——
化学信息
-
CAS Number472981-92-3
-
分子量287.74
-
分子式C16H14ClNO2
-
纯度>98% (HPLC)
-
溶解度DMSO : ≥ 39 mg/mL 135.54 mM; H2O : < 0.1 mg/mL
-
SMILESCOC1=CC=CC(=C1)NC(=O)/C=C/C2=CC=C(C=C2)Cl
-
化学全称3-(4-chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Gunthorpe MJ,et al. Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist. Neuropharmacology. 2004 Jan;46(1):133-49.
产品手册
关联产品
-
(Z)-3-Hexenyl tiglat...
(Z)-3-Hexenyl tiglate ((3Z)-Hex-3-en-1-yl (2E)-2-methylbut-2-enoate) is a RIFM fragrance that can be used in paints, coatings, inks, resins and other fields.
-
2A/2B Dengue Proteas...
2A/2B Dengue Protease Substrate
-
[Sar9,Met(O2)11]-Sub...
[Sar9,Met(O2)11]-Substance P TFA is a selective tachykinin NK1 receptor agonist.[Sar9,Met(O2)11]-Substance P and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissimilar time-course. Both agonists increase dose-dependently face washing and sniffing while [Sar9,Met(O2)11]-Substance P is the sole to produce grooming.
