Irisflorentin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Irisflorentin 通过促进 rpn-3 表达、增强蛋白酶体活性和下调 egl-1 表达来发挥作用，从而阻断细胞凋亡途径。

Irisflorentin blocks apoptosis pathways, by exerting its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-1 expression. Irisflorentin has anti-inflammatory mechanism in LPS-activated RAW 264.7 macrophages, by reducing the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO.(In Vitro):Irisflorentin does not affect the LPS-stimulated RAW 264.7 macrophages viability up to a concentration of 40 μM.Irisflorentin (10-40 μM) inhibits the LPS-induced production of NO in a concentration-dependent manner without affecting the iNOS activity in RAW 264.7 macrophages.Irisflorentin (10-40 μM) concentration dependently inhibits the LPS (10 ng/mL)-induced increase in iNOS mRNA expression in LPS stimulated RAW 264.7 macrophages. Irisflorentin (10-40 μM) concentration-dependently suppresses the production of TNF-α, IL-1β and IL-6 in LPS stimulated RAW 264.7 macrophages.Irisflorentin (10-40 μM) concentration dependently inhibits the LPS (10 ng/mL)-induced increase in iNOS protein levels. Irisflorentin (10-40 μM) concentration-dependently suppresses LPS-induced p38 and ERK1/2 phosphorylation in a concentration-dependent manner, but slightly affects JNK phosphorylation.

Irisflorentin does not affect the LPS-stimulated RAW 264.7 macrophages viability up to a concentration of 40 μM. Irisflorentin (10-40 μM) inhibits the LPS-induced production of NO in a concentration-dependent manner without affecting the iNOS activity in RAW 264.7 macrophages. Irisflorentin (10-40 μM) concentration dependently inhibits the LPS (10 ng/mL)-induced increase in iNOS mRNA expression in LPS stimulated RAW 264.7 macrophages. Irisflorentin (10-40 μM) concentration-dependently suppresses the production of TNF-α, IL-1β and IL-6 in LPS stimulated RAW 264.7 macrophages.Irisflorentin (10-40 μM) concentration dependently inhibits the LPS (10 ng/mL)-induced increase in iNOS protein levels. Irisflorentin (10-40 μM) concentration-dependently suppresses LPS-induced p38 and ERK1/2 phosphorylation in a concentration-dependent manner, but slightly affects JNK phosphorylation. RT-PCRCell Line:LPS-stimulated RAW 264.7 macrophages Concentration:10, 20, 40 μM Incubation Time:Result:Inhibited the LPS (10 ng/mL)-induced increase in iNOS mRNA expression. Suppressed the production of TNF-α, IL-1β and IL-6. Western Blot Analysis Cell Line:LPS-stimulated RAW 264.7 macrophagesConcentration:10, 20, 40 μM Incubation Time:Result:Inhibited the LPS (10 ng/mL)-induced increase in iNOS protein levels.Suppressed LPS-induced p38 and ERK1/2 phosphorylation, but slightly affected JNK phosphorylation.

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Others

Other Targets

Others

Others-Field

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41743-73-1

386.35

C20H18O8

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (129.42 mM)

COC1=CC(=CC(=C1OC)OC)C2=COC3=CC4=C(C(=C3C2=O)OC)OCO4

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(-20℃)

With Ice Pack

≥ 2 years