UK 383367 ( UK-383367, UK 383367, UK383367 )

产品货号. M18461 CAS No. 348622-88-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

UK 383367
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

UK-383367 是一种前胶原 C 蛋白酶抑制剂，IC50 为 44 nM，比 MMP 具有优异的选择性。
产品描述

UK-383367 is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase; PCP) (IC50 = 44 nM). Bone morphogenic protein 1 (BMP1) is an enzyme responsible for the cleavage and maturation of growth factors and ECM proteins. The purpose of our study was to determine whether cultured human trabecular meshwork (TM) cells express BMP1, BMP1 expression is regulated by TGF-β2, BMP1 is biologically active, and BMP1 regulates LOX activity.
体外实验

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体内实验

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同义词

UK-383367, UK 383367, UK383367
通路

MAPK/ERK Signaling
靶点

p38 MAPK
受体

Procollagen C proteinase
研究领域

Others-Field
适应症

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CAS Number

348622-88-8
分子量

324.38
分子式

C15H24N4O4
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 65 mg/mL (200.38 mM)
SMILES

NC(=O)C1=NOC(=N1)[C@H](CCCC1CCCCC1)CC(=O)NO
化学全称

(R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide