Harmine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

盐酸骆驼蓬碱是从骆驼蓬属中提取的。

Harmine hydrochloride is extracted from Peganum Harmala Genus.(In Vitro):Harmine inhibits tau phosphorylation by DYRK1A by selected DANDYs, with an IC50 of 190 nM. Harmine negatively regulates homologous recombination (HR) by interfering Rad51 recruitment, resulting in severe cytotoxicity in hepatoma cells. Furthermore, NHEJ inhibitor Nu7441 markedly sensitizes Hep3B cells to the anti-proliferative effects of Harmine.(In Vivo):It is shown that brain water content is significantly increased in the TBI group. Treatment with Harmine significantly reduces the tissue water content at 1, 3 and 5 days, compared with the TBI group. Harmine treatment significantly reduces the escape latency at 3 and 5 days, compared with the TBI group. Post-TBI administration of Harmine significantly improves the motor function recovery of the rats at 1, 3 and 5 days following TBI, compared with the TBI group without Harmine treatment. The neuronal survival rate in the Harmine-treated group is significantly increased, compared with the TBI group. Administration of Harmine results in marked elevation in the expression of GLT-1, compared with the TBI group. The administration of Harmine significantly reduces the expression of caspase 3, compared with the TBI group.

Harmine inhibits tau phosphorylation by DYRK1A by selected DANDYs, with an IC50 of 190 nM. Harmine negatively regulates homologous recombination (HR) by interfering Rad51 recruitment, resulting in severe cytotoxicity in hepatoma cells. Furthermore, NHEJ inhibitor Nu7441 markedly sensitizes Hep3B cells to the anti-proliferative effects of Harmine.

It is shown that brain water content is significantly increased in the TBI group. Treatment with Harmine significantly reduces the tissue water content at 1, 3 and 5 days, compared with the TBI group. Harmine treatment significantly reduces the escape latency at 3 and 5 days, compared with the TBI group. Post-TBI administration of Harmine significantly improves the motor function recovery of the rats at 1, 3 and 5 days following TBI, compared with the TBI group without Harmine treatment. The neuronal survival rate in the Harmine-treated group is significantly increased, compared with the TBI group. Administration of Harmine results in marked elevation in the expression of GLT-1, compared with the TBI group. The administration of Harmine significantly reduces the expression of caspase 3, compared with the TBI group.

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Others

Other Targets

GluR1

Others-Field

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343-27-1

248.71

C13H13ClN2O

>98% (HPLC)

In Vitro:?H2O : 10 mg/mL (40.21 mM助)

COc1ccc2c(c1)[nH]c1c2ccnc1C.Cl

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(-20℃)

With Ice Pack

≥ 2 years