(20S)-Protopanaxatriol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(20S)-原人参三醇(g-PPT)是人参皂苷的代谢产物，可通过雌激素受体和糖皮质激素受体调节内皮细胞功能。

(20S)-Protopanaxatriol(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.

(20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and oestrogen receptor (ER) in human umbilical vein endothelial cells (HUVECs). (20S)-Protopanaxatriol (PPT) increases [Ca2+]i with an EC50 of 482 nM in HUVECs. ((20S)-Protopanaxatriol (1 μM) elevates NO production via ERβ. (20S)-Protopanaxatriol inhibits the autonomous transactivation of Gal4-LXRα LBD, the T0901317-dependent transcription of SREBP-1c and its promoter. (20S)-Protopanaxatriol (10 μg/mL) blocks the recruitment of RNA polymerase II to the LXRE region of SREBP-1c. (20S)-Protopanaxatriol also inhibits T0901317-dependent transcription of LXRα target genes related to lipogenesis, and reduces T0901317-induced cellular triglyceride (TG) accumulation in primary hepatocytes, but does not alter transcription of ABCA1, also an LXRα target gene.Both In HCC827GR and H1975 cell lines, g-PPT (100?nM, 1?μM, 10?μM, 20?μM; 48 hours) results in SCD1 expression decreased.

(20S)-Protopanaxatriol (10?mg/kg; i.p.; daily for four weeks) synergizes with Gefitinib to inhibit xenograft growth.(20S)-Protopanaxatriol (50-100 mg/kg; p.o.; 25 days; female BALB/c nude mice bearing breast cancer MCF-7 cell) inhibits the growth of MCF-7 breast cancer cells in a nude mice xenograft assay. Animal Model:H1975 murine xenograft tumor model Dosage:10?mg/kg Administration:I.p.; daily for four weeks Result:The combined g-PPT and Gefitinib (50 mg/kg/day) treatment clearly reduced p-EGFR and KI67 expression and increased c-Caspase3 expression compared to Gefitinib or g-PPT treatment alone.

20(S)-APPT | g-PPT

Cell Cycle/DNA Damage

DNA/RNA Synthesis

Others

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34080-08-5

476.73

C30H52O4

>98% (HPLC)

DMSO : ≥ 47 mg/mL;98.59 mM

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(-20℃)

With Ice Pack

≥ 2 years