SC-202671 ( TCS JNK 5a, TCS-JNK-5a, JNK Inhibitor IX, SC-202671 )

产品货号. M18411 CAS No. 312917-14-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SC-202671
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

TCS JNK 5a 是 JNK3(pIC50= 6.7)、JNK2(pIC50=6.5) 的有效、特异性抑制剂。
产品描述

TCS JNK 5a, also called JNK Inhibitor IX , is a selective and potent inhibitor of JNK inhibitor. Exposure of human Jurkat T cells to SC-202671 targeting JNK2 and JNK3, caused apoptotic DNA fragmentation along with G2/M arrest, phosphorylation of Bcl-2, Mcl-1, and Bim, Δψm loss, and activation of Bak and caspase cascade.
体外实验

TCS JNK 5a is also screened in a panel of more than 30 kinase assays, including Alk5, c-Fms, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, Tie-2 and VegFr2, and is inactive (pIC50<5.0) against all of them.
体内实验

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同义词

TCS JNK 5a, TCS-JNK-5a, JNK Inhibitor IX, SC-202671
通路

Others
靶点

Other Targets
受体

JNK2| JNK3
研究领域

Inflammation/Immunology
适应症

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1. Angell RM, et al. Bioorg Med Chem Lett. 2007, 17(5), 1296-1301.2. Rudolf E, et al. Toxicol Lett. 2009, 188(3), 236-242.

计算器

产品手册

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