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L-685,458
CAS No. 292632-98-5
L-685,458 ( L685458 | L-685458 | L 685458 )
产品货号. M18379 CAS No. 292632-98-5
L-685, 458 是 A beta PP gamma 分泌酶活性的特异性有效抑制剂，Ki 为 17 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3544 | 有现货 |
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| 10MG | ￥5178 | 有现货 |
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| 25MG | ￥7831 | 有现货 |
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| 50MG | ￥10509 | 有现货 |
|
| 100MG | ￥13770 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥4513 | 有现货 |
|
生物学信息
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产品名称L-685,458
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述L-685, 458 是 A beta PP gamma 分泌酶活性的特异性有效抑制剂，Ki 为 17 nM。
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产品描述L685458 is a potent and selective γ -secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. L685458 also exhibits equal potency for inhibition of A β 40 and A β 42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro.
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体外实验——
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体内实验Animal Model:NOD-SCID Mouse Hepatoma Model Dosage:5 mg/kg Administration:Percutaneous administration; 5 mg/kg; 2 weeks Result:Exhibited anti-tumor activities in vivo.
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同义词L685458 | L-685458 | L 685458
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通路Others
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靶点Other Targets
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受体γ secretase
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研究领域Neurological Disease
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适应症——
化学信息
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CAS Number292632-98-5
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分子量672.85
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分子式C39H52N4O6
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 31 mg/mL; 46.07 mM
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SMILESCC(C)C[C@H](NC(=O)[C@@H](C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
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化学全称tert-butyl ((2S,3R,5R)-6-(((S)-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl)carbamate.
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Shearman M S, Beher D, Clarke E E, et al. L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid β-protein precursor γ-secretase activity[J]. Biochemistry, 2000, 39(30): 8698-8704.
产品手册
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