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alpha-Asarone
CAS No. 2883-98-9
alpha-Asarone ( α-Asarone | trans-Asarone )
产品货号. M18369 CAS No. 2883-98-9
α-细辛脑是一种精神活性化合物，对小鼠具有抗抑郁样活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | ￥89 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥94 | 有现货 |
|
生物学信息
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产品名称alpha-Asarone
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述α-细辛脑是一种精神活性化合物，对小鼠具有抗抑郁样活性。
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产品描述Alpha-Asarone is a psychoactive compound with antidepressant-like activity in mice.(In Vitro):The results indicated that α-asarone significantly attenuated the LPS-stimulated increase in neuroinflammatory responses and suppressed pro-inflammatory cytokine production in BV-2 cells. Mechanistic study revealed that alpha-Asarone (α-Asarone) inhibited the LPS-stimulated activation via regulation of nuclear factor kappa-B by blocking degradation of inhibitor kappa B-alpha signaling in BV-2 microglial cells.(In Vivo):The present results reveal that the acute treatment of alpha-Asarone (α-Asarone) elicited biphasic responses on immobility such that the duration of the immobility time is significantly reduced at lower doses (15 and 20 mg/kg, i.p.) but increased at higher doses (50 and 100 mg/kg, i.p.) in the TST. Besides, alpha-Asarone (α-Asarone) at higher doses (50 and 100 mg/kg, i.p.) significantly decreased the spontaneous locomotor activity.
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体外实验The results indicated that α-asarone significantly attenuated the LPS-stimulated increase in neuroinflammatory responses and suppressed pro-inflammatory cytokine production in BV-2 cells. Mechanistic study revealed that alpha-Asarone (α-Asarone) inhibited the LPS-stimulated activation via regulation of nuclear factor kappa-B by blocking degradation of inhibitor kappa B-alpha signaling in BV-2 microglial cells.
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体内实验The present results reveal that the acute treatment of alpha-Asarone (α-Asarone) elicited biphasic responses on immobility such that the duration of the immobility time is significantly reduced at lower doses (15 and 20 mg/kg, i.p.) but increased at higher doses (50 and 100 mg/kg, i.p.) in the TST. Besides, alpha-Asarone (α-Asarone) at higher doses (50 and 100 mg/kg, i.p.) significantly decreased the spontaneous locomotor activity.
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同义词α-Asarone | trans-Asarone
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通路Others
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靶点Other Targets
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受体HMGCR| CYP2D6| CYP3A4
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研究领域Neurological Disease
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适应症——
化学信息
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CAS Number2883-98-9
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分子量208.3
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分子式C12H16O3
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纯度>98% (HPLC)
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溶解度DMSO : 100 mg/mL 480.19 mM; H2O : < 0.1 mg/mL
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SMILESC/C=C/c1cc(c(cc1OC)OC)OC
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Limón, L, et al. Neuroscience Letters 453(2), 2009, 98-103.
