Bisdemethoxycurcumin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

双去甲氧基姜黄素 (BDMC) 是姜黄素的天然去甲氧基衍生物。

Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression.

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Curcumin III, Bisdemethoxycurcumin

Others

Other Targets

p300|Wnt/β-catenin

Cancer

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24939-16-0

308.33

C19H16O4

>98% (HPLC)

In Vitro:?DMSO : 66.67 mg/mL (216.23 mM)

Oc2ccc(/C=C/C(=O)CC(=O)/C=C/c1ccc(O)cc1)cc2

(1E,6E)-1,7-Bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione

(-20℃)

With Ice Pack

≥ 2 years