Porcupine-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Porcupine-IN-1 是一种有效的豪猪抑制剂 (IC50: 0.5±0.2 nM)。

MDK-4774, Porcupine-IN-1, is a Porcupine inhibitor.

Porcupine is an enzyme that catalyses the addition of palmitoleate to a serine residue in Wnt proteins, a process which is required for the secretion of Wnt proteins. Porcupine-IN-1 is as potent as the clinical compound LGK974 in a cell based STF reporter gene assay. Porcn-IN-1 potently inhibits the secretion of Wnt3A, therefore is confirmed to be a porcupine inhibitor.

Porcn-IN-1 demonstrates moderate clearance under the treatment of human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg). It exhibits high clearance when treated with mouse microsomes (109 mL/min/kg).

Porcupine-IN-1 | MDK-4774 | MDK 4774 | MDK4774

Others

Other Targets

Porcupine

Cancer

——

2036044-77-4

410.44

C25H19FN4O

>98% (HPLC)

DMSO : ≥ 100 mg/mL; 243.64 mM

Cc1cc(ccn1)-c1ncc(CNC(=O)c2ccc3c(c2)[nH]c2ccccc32)cc1F

N-((3-Fluoro-2’-methyl[2,4’-bipyridin]-5-yl)methyl)-9H-carbazole-2-carboxamide

(-20℃)

With Ice Pack

≥ 2 years