Bucladesine sodium salt

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Bucladesine 是 PKA 激活剂，是一种环核苷酸衍生物，可模拟内源性 cAMP 的作用，并能够渗透细胞膜。

Bucladesine sodium is a cardiac stimulant.(In Vitro):Both choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) mRNA increased approximately fourfold after treatment of PC12 cells with Bucladesine (dibutyryl cyclic AMP; dbcAMP). ChAT and PKA activity are also increased by Bucladesine.(In Vivo):Intrahippocampal infusion of Bucladesine into the CA1 region (male Albino-Wistar rats) can cause an improvement in spatial memory in maze task. Bilateral infusion of 10 μM and 100 μM Bucladesine leads to a significant reduction in escape latency and travel distance (showing an improvement in spatial memory). Bucladesine via activation of PKA and induction of cAMP/PKA pathway improved spatial memory retention.

Both choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) mRNA increased approximately fourfold after treatment of PC12 cells with Bucladesine (dibutyryl cyclic AMP; dbcAMP). ChAT and PKA activity are also increased by Bucladesine.

Intrahippocampal infusion of Bucladesine into the CA1 region (male Albino-Wistar rats) can cause an improvement in spatial memory in maze task. Bilateral infusion of 10 μM and 100 μM Bucladesine leads to a significant reduction in escape latency and travel distance (showing an improvement in spatial memory). Bucladesine via activation of PKA and induction of cAMP/PKA pathway improved spatial memory retention.

Bucladesine sodium | DbcAMP sodium

Others

Other Targets

PKA

Others-Field

——

16980-89-5

491.37

C18H23N5NaO8P

>98% (HPLC)

DMSO : 150 mg/mL 305.27 mM;H2O : ≥ 42 mg/mL 85.48 mM

CCCC(=O)NC1=NC=NC2=C1N=CN2C3C(C4C(O3)COP(=O)(O4)[O-])OC(=O)CCC.[Na+]

sodium (4aR,6R,7R,7aR)-6-(6-butyramido-9H-purin-9-yl)-7-(butyryloxy)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide

(-20℃)

With Ice Pack

≥ 2 years