AZD3759 hydrochloride ( —— )

产品货号. M18097 CAS No. 1626387-81-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

AZD3759 hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

AZD3759（盐酸盐）是一种有效的、口服活性的、中枢神经系统渗透性 EGFR 抑制剂。
产品描述

AZD3759 (hydrochloride) is an effective, orally active and central nervous system-penetrant?EGFR?inhibitor. At Km?ATP concentrations, the?IC50s are 0.2/0.3/0.2 nM for EGFR (L858R)/EGFR (wt)/EGFR (exon 19Del).
体外实验

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体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

EGFR (exon 19De)| EGFR (L858R)| EGFR (wt)
研究领域

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适应症

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CAS Number

1626387-81-2
分子量

496.36
分子式

C22H24Cl2FN5O3
纯度

>98% (HPLC)
溶解度

——
SMILES

C[C@@H]1CN(CCN1C(=O)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC)C.Cl
化学全称

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1. Zeng Q, et al. J Med Chem. 2015 Oct 22;58(20):8200-15.

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