Balsalazide disodium salt dihydrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Balsalazide 是一种抗炎化合物，用于治疗炎症性肠病。Balsalazide 是一种新的含有 5-氨基水杨酸 (5-ASA) 的前药。

Balsalazide Disodium is the disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Mesalazine acts locally on the mucosa of the colon where it diminishes inflammation by blocking the production of arachidonic acid metabolites and other inflammatory agents. Balsalazide disodium is used to treat chronic inflammatory bowel disease.(In Vivo):At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug.

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At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug.

Balsalazide Disodium | balsalazide | BX 661A | Colazal | Colazide

Others

Other Targets

STAT

Inflammation/Immunology

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150399-21-6

437.31

C17H17N3Na2O8

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (285.84 mM)

[Na+].[Na+].O.O.O=C([O-])c1cc(ccc1O)/N=N/c2ccc(cc2)C(=O)NCCC([O-])=O

5-[4-(2-Carboxyethylcarbamoyl)phenylazo]salicylic Acid Disodium Salt Dihydrate

(-20℃)

With Ice Pack

≥ 2 years