Picolinamide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Picolinamide 被发现是大鼠胰岛细胞核聚 (ADP-核糖) 合成酶的强抑制剂。

Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.

Picolinamide (10 μM-1 mM) inhibits Poly(ADP-ribose) synthetase activity.Picolinamide (2 mM) protects against streptozotocin-induced depression of proinsulin synthesis in isolated pancreatic islets of rats.

Picolinamide (4 mmol/kg, i.p., rats) inhibits Na+/phosphate cotransport by isolated renal brush border membrane vesicles.Picolinamide (250 mg/kg, i.p., rats) enhances the tumorigenic effect of Streptozotocin and Alloxan on islet B-cells. Animal Model:Rats Dosage:4 mmol/kg Administration:Intraperitoneal injection (i.p.)Result:Increased renal cortical NAD content (1.5 fold).

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Others

Other Targets

PARP

Cancer

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1452-77-3

122.12

C6H6N2O

>98% (HPLC)

In Vitro:?H2O : 100 mg/mL (818.87 mM)

C1=CC=NC(=C1)C(=O)N

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(-20℃)

With Ice Pack

≥ 2 years