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CGP 52432
CAS No. 139667-74-6
CGP 52432 ( Cgp 52432 | Cgp52432 | Cgp52432 )
产品货号. M17994 CAS No. 139667-74-6
CGP52432 是一种非常有效的 GABAB 受体拮抗剂 (IC50 = 85 nM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥777 | 有现货 |
|
| 10MG | ￥1378 | 有现货 |
|
| 25MG | ￥2409 | 有现货 |
|
| 50MG | ￥3618 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥839 | 有现货 |
|
生物学信息
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产品名称CGP 52432
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CGP52432 是一种非常有效的 GABAB 受体拮抗剂 (IC50 = 85 nM)。
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产品描述Cgp 52432 is a GABA-A receptor antagonist.
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体外实验CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM, 35- and 100-fold lower than at the receptors regulating somatostatin and glutamate overflow, respectively.
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体内实验CGP52432 (10, 30 mg/kg) shows no effect on the total arm entries and total head dips of mice on the elevated-plus maze. CGP52432 (100 nmol/kg, i.v., or 1 nmol/kg, i.c.v.) abolishes the suppressive effects of GABA ( 50 μmol/kg, i.v.) on enhanced renal sympathetic nerve activity (RSNA) during ischaemia, causeing elimination of the renoprotective effects of GABA in rats.
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同义词Cgp 52432 | Cgp52432 | Cgp52432
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通路Others
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靶点Other Targets
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受体GABAB
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研究领域Neurological Disease
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适应症——
化学信息
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CAS Number139667-74-6
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分子量384.23
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分子式C15H24Cl2NO4P
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纯度>98% (HPLC)
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溶解度DMSO : 5 mg/mL 13.01 mM;
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SMILESCCOC(OCC)P(=O)(CCCNCC1=CC(=C(C=C1)Cl)Cl)O
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化学全称Phosphinic acid, (3-(((3,4-dichlorophenyl)methyl)amino)propyl)(diethoxymethyl)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Bonanno G,etal.GABA(B) receptors as potential targets for drugs able to prevent excessive excitatory amino acid transmission in the spinal cord.Eur J Pharmacol. 1998 Dec 4;362(2-3):143-8.
产品手册
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