CGP 52432

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CGP52432 是一种非常有效的 GABAB 受体拮抗剂 (IC50 = 85 nM)。

Cgp 52432 is a GABA-A receptor antagonist.

CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM, 35- and 100-fold lower than at the receptors regulating somatostatin and glutamate overflow, respectively.

CGP52432 (10, 30 mg/kg) shows no effect on the total arm entries and total head dips of mice on the elevated-plus maze. CGP52432 (100 nmol/kg, i.v., or 1 nmol/kg, i.c.v.) abolishes the suppressive effects of GABA ( 50 μmol/kg, i.v.) on enhanced renal sympathetic nerve activity (RSNA) during ischaemia, causeing elimination of the renoprotective effects of GABA in rats.

Cgp 52432 | Cgp52432 | Cgp52432

Others

Other Targets

GABAB

Neurological Disease

——

139667-74-6

384.23

C15H24Cl2NO4P

>98% (HPLC)

DMSO : 5 mg/mL 13.01 mM;

CCOC(OCC)P(=O)(CCCNCC1=CC(=C(C=C1)Cl)Cl)O

Phosphinic acid, (3-(((3,4-dichlorophenyl)methyl)amino)propyl)(diethoxymethyl)-

(-20℃)

With Ice Pack

≥ 2 years