Alprenolol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Alprenolol 是一种非选择性 β-肾上腺素能受体 (β-AR) 拮抗剂，也是血清素 (5-HT) 受体亚型 5-HT1A 和 5-HT1B 的拮抗剂。

Alprenolol is a non-selective β-adrenergic receptor (β-AR) antagonist that is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1B.(In Vivo):heart rate by 39 beats/min (at 3-hr) in conscious renal hypertensive dogs.Alprenolol (i.p., 5 mg/kg) effectively blockes the anxiolytic effects of indorenate and ipsapirone but do not reduce the motor activity in adult male Swiss Webster mice.Alprenolol (intravenous injection, 0.5 or 1.0 mg/kg) can decrease systolic pressure by a mean of 10 mm Hg, diastolic pressure by a mean of 10 mm Hg) and heart rate by 23 beats/min, as well as slightly reduce both myocardial and liver blood flows by mean of 17% and 15% respectively at a dose of 1.0 mg/kg in cats.

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Alprenolol (p.o., 50 mg/kg) causes a significant drop in blood pressure which averages 20 mm Hg (at 3-hr) and an increase in heart rate by 39 beats/min (at 3-hr) in conscious renal hypertensive dogs.Alprenolol (i.p., 5 mg/kg) effectively blockes the anxiolytic effects of indorenate and ipsapirone but do not reduce the motor activity in adult male Swiss Webster mice.Alprenolol (intravenous injection, 0.5 or 1.0 mg/kg) can decrease systolic pressure by a mean of 10 mm Hg, diastolic pressure by a mean of 10 mm Hg) and heart rate by 23 beats/min, as well as slightly reduce both myocardial and liver blood flows by mean of 17% and 15% respectively at a dose of 1.0 mg/kg in cats.

(RS)-Alprenolol | dl-Alprenolol

Chromatin/Epigenetic

Epigenetic Reader Domain

β-adrenergic receptor| 5-HT

Cancer

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13655-52-2

249.35

C15H23NO2

>98% (HPLC)

DMSO : ≥ 100 mg/mL 401.04 mM; H2O : < 0.1 mg/mL

CC(C)NCC(O)COc1ccccc1CC=C

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(-20℃)

With Ice Pack

≥ 2 years