(-)-MK 801 Maleate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MK-801 是一种有效的、选择性的、非竞争性的 NMDA 受体拮抗剂，在大鼠脑膜中的 Kd 为 37.2 nM。

MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.

(-)-Dizocilpine maleate ((-)-MK-801 maleate) significantly inhibited the uptake of all three (norepinephrine, dopamine and serotonin) monoamine transporters in a dose-dependent manner in HEK cells. The Ki values of (-)-Dizocilpine on the norepinephrine, dopamine and serotonin transporters are 3.7 μM, 40 μM and 47 μM, respectively.

(-)-Dizocilpine maleate (0.1 mg/kg; intraperitoneal injection; male adult C57BL/6 mice) treatment induces rapid antidepressant effects in the social defeat stress model. Animal Model:Male adult C57BL/6 mice ( 20-25g; aged 8 weeks) with social defeat stress model Dosage:0.1 mg/kg Administration:Intraperitoneal injection Result:Induced rapid antidepressant effects in the social defeat stress model.

(-)-MK 801 (Maleate)

Others

Other Targets

NMDA Receptor

Neurological Disease

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121917-57-5

337.37

C20H19NO4

>98% (HPLC)

DMSO : ≥ 30 mg/mL; 88.92 mM

O=C(O)/C=C\C(=O)O.C[C@]42N[C@@H](Cc1ccccc12)c3ccccc34

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(-20℃)

With Ice Pack

≥ 2 years