SRT3109

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SRT3109 是一种 CXCR2 配体，用于治疗趋化因子介导的疾病和病症。

SRT3109 is a CXCR2 ligand. CXCR2 ligands are potent chemoattractants for neutrophils and play a key role in the emigration of neutrophils from the blood to sites of tissue inflammation. Moreover, CXCR2 signaling may also regulate neutrophil mobilization from the bone marrow. Deletion of the chemokine receptor CXCR2 prevents the recruitment of neutrophils into tissues and subsequent development of experimental Lyme arthritis.

SRT3109 (Example 1) is an antagonist of CXCR2, with a pIC50 of 8.2, and used in the research of chemokine mediated diseases.

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SRT3109 | SRT-3109

Others

Other Targets

CXCR2

Inflammation/Immunology

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1204707-71-0

475.53

C18H23F2N5O4S2

>98% (HPLC)

DMSO : ≥ 100 mg/mL; 210.29 mM

C[C@H]([C@H](CO)O)Nc1cc(nc(n1)SCc1c(c(ccc1)F)F)NS(=O)(=O)N1CCC1

N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3R)-3,4-dihydroxybutan-2-yl)amino)pyrimidin-4-yl)azetidine-1-sulfonamide

(-20℃)

With Ice Pack

≥ 2 years