SAR131675 (b) ( SAR131675 | SAR 131675 | SAR-131675 )

产品货号. M17805 CAS No. 1092539-44-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SAR131675 (b)
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SAR131675 是一种有效且特异性的 VEGFR-3 抑制剂。它分别抑制 HEK 细胞中的 VEGFR-3 酪氨酸激酶活性 (IC50: 20 nmol/L) 和 VEGFR-3 自磷酸化 (IC50: 45 nmol/L)。
产品描述

SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC(50) values of 20 and 45 nmol/L, respectively. SAR131675 was found to be highly selective for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 is the first highly specific VEGFR-3-TK inhibitor described to date, displaying significant antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion.
体外实验

SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM.
体内实验

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同义词

SAR131675 | SAR 131675 | SAR-131675
通路

Others
靶点

Other Targets
受体

VEGFR3
研究领域

Cancer
适应症

——

CAS Number

1092539-44-0
分子量

358.16
分子式

C18H22N4O4
纯度

>98% (HPLC)
溶解度

——
SMILES

CCn1c(c(c(=O)c2c1nc(cc2)C#CC(C)(COC)O)C(=O)NC)N
化学全称

2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

1. Yu J, et al. Biochem Biophys Res Commun. 2016 Mar 25;472(1):182-8.

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