FPH2 ( BRD-9424 )

产品货号. M17692 CAS No. 957485-64-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

FPH2
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

FPH2 (BRD-9424) 是一种促进 iPS 衍生肝细胞分化的小分子。
产品描述

FPH2 (BRD-9424) is a small molecule promoting differentiation of iPS-derived hepatocytes.
体外实验

FPH2 induces functional proliferation of hepatocytes in vitro, and thus may be useful for expanding mature human primary hepatocytes. FPH1 and FPH2 can increase in hepatocyte nuclei count and/or elevate the number of nuclei undergoing mitosis during primary screening, and these effects on hepatocytes are concentration dependent. Cells treated with FPH1 and FPH2 also maintain their liver-specific functions. Over 7 days, FPH2 induces hepatocyte doublings at a rate that is consistent with reported liver regeneration kinetics in vivo.
体内实验

——
同义词

BRD-9424
通路

MAPK/ERK Signaling
靶点

p38 MAPK
受体

Others
研究领域

Others-Field
适应症

——

1. Shan J, et al. Nat Chem Biol. 2013, 9(8), 514-520.

计算器

产品手册

关联产品

CC-99677

Gamcemetinib (CC-99677) 是一种有效的、共价的、不可逆的丝裂原活化蛋白 (MAP) 激酶活化蛋白激酶 -2 (MK2)通路抑制剂，在生化(IC50=156.3 nM) 和细胞基础检测 (EC50=89 nM) 中均有作用。Gamcemetinib 来自专利 WO2020236636，化合物 1。
p38-α MAPK-IN-1

p38-α MAPK-IN-1 是一种 MAPK14 (p38-α) 抑制剂，在 EFC 置换试验和 HTRF 试验中 IC50 分别为 2300 nM 和 5500 nM。
TA-02

一种有效的 p38 MAPK 抑制剂，IC50 为 20 nM。