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(±)-trans-ACPD
CAS No. 67684-64-4
(±)-trans-ACPD ( trans-ACPD )
产品货号. M17567 CAS No. 67684-64-4
(±)-trans-ACPD 是 (1S, 3R)- 和 (1R, 3S)-ACPD 的等分子混合物。 (±)-trans-ACPD 是 mGluR（代谢型谷氨酸受体）的选择性激动剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥653 | 有现货 |
|
| 10MG | ￥1026 | 有现货 |
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| 25MG | ￥2009 | 有现货 |
|
| 50MG | ￥3004 | 有现货 |
|
| 100MG | ￥4383 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥559 | 有现货 |
|
生物学信息
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产品名称(±)-trans-ACPD
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述(±)-trans-ACPD 是 (1S, 3R)- 和 (1R, 3S)-ACPD 的等分子混合物。 (±)-trans-ACPD 是 mGluR（代谢型谷氨酸受体）的选择性激动剂。
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产品描述(±)-trans-ACPD is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD. (±)-trans-ACPD is a selective agonist of the mGluR (metabotropic glutamate receptor); active at the group I/II mGlu receptors (EC50: 2/15/23/800 μM, mGluR2/1/5/4).
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体外实验Excitatory amino acid (EAA) analogues activate receptors that are coupled to the increased hydrolysis of phosphoinositides (PIs). In these studies, hippocampal slices are prepared from neonatal rats (6-11 days old) to characterize the effects of EAA analogues on these receptors. The concentrations of trans-ACPD required to evoke half-maximal stimulation (EC50 value) is 51 μM. DL-2-Amino-3-phosphonopropionate (DL-AP3) is also equipotent as an inhibitor of PI hydrolysis stimulated by ibotenate, quisqualate, and trans-ACPD (IC50 values are 480-850 μM).
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体内实验Intrathecal injection of NMDA, kainate, and trans-ACPD, TNF-α, or IL-1β causes significant (p<0.001) biting behaviour in mice compared to animals injected intrathecally with saline. In all groups, systemic pre-treatment with GM (100 mg/kg, i.p.) significantly (p<0.001) reduces the biting behaviour compared to mice treated with saline (10 mL/kg, i.p.). The greatest effect of GM is observed on the pro-inflammatory cytokines and NMDA, with the following inhibition percentages: TNF-α (92±7%), IL-1β (91±5%), NMDA (69±1%), and trans-ACPD (71±12%). By contrast, at the same dose, GM has no significant effect on the kainate-mediated biting response.
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同义词trans-ACPD
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通路Others
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靶点Other Targets
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受体Calcium Channel
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研究领域Metabolic Disease
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适应症——
化学信息
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CAS Number67684-64-4
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分子量173.17
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分子式C7H11NO4
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纯度>98% (HPLC)
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溶解度H2O : 6.2 mg/mL. 35.80 mM;
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SMILES[C@@]1(C[C@H](CC1)C(=O)O)(C(=O)O)N
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化学全称(±)-1-Aminocyclopentane-trans-1,3-dicarboxylic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Conti P,et al.Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid.Farmaco. 2002 Nov;57(11):889-95.
产品手册
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