Jervine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Jervine 的生物活性是通过其与 7 次跨膜蛋白 Smoothened 的相互作用介导的。 Jevine 结合并抑制平滑。

The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.

Jervine (40 μM; 6, 12 and 24 hours) inhibits Akt phosphorylation. Jervine (40 μM; 2 hours) inhibits NF-jB activation decreased COX-2 overexpression and induced apoptosis. Western Blot Analysis Cell Line:HEL and TF1a cells Concentration:40 μM Incubation Time:6, 12 and 24 hours Result:Inhibited Akt phosphorylation.

Jervine (orally; 50-400 mg/kg) exerts 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema. Animal Model:Male Sprague Dawley rats (180-200? g)Dosage:50, 100, 200 and 400? mg/kg Administration:Orally Result:Exerted 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema.

11-Ketocyclopamine

Others

Other Targets

Hedgehog| Smoothened

Cancer

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469-59-0

425.61

C27H39NO3

>98% (HPLC)

DMSO : 1 mg/mL2.35 mM;

O=C1C2=C(C)[C@]3(CC[C@H]2[C@@H]2CC=C4C[C@H](CC[C@]4(C)[C@@H]12)O)O[C@@H]1C[C@@H](CN[C@H]1[C@H]3C)C

——

(-20℃)

With Ice Pack

≥ 2 years