Syk Inhibitor II (hydrochloride)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

脾酪氨酸激酶 (Syk) 是一种非受体酪氨酸激酶，磷酸化后，与 FcRγ 链基于免疫受体酪氨酸的激活基序结合，并介导与血小板功能和炎症相关的下游信号传导。

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively).

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Others

Other Targets

Syk| PKCε| PKCβII| ZAP-70| Btk| Itk

Infection

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227449-73-2

413.22

C14H17Cl2F3N6O

>98% (HPLC)

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NCCNC1=NC(NC2=CC(C(F)(F)F)=CC=C2)=C(C(N)=O)C=N1.Cl.Cl

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(-20℃)

With Ice Pack

≥ 2 years