Solamargine ( Solamargin | δ-Solanigrine )

产品货号. M17419 CAS No. 20311-51-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

Solamargine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Solamargine 是从中药 Solanum nigrum L. (SNL) 中提取的主要甾体生物碱苷；已被证明可以抑制多种癌细胞的生长并诱导其凋亡。
产品描述

Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cells.
体外实验

Solamargine (15 μg/ml; 72 hours) predominantly stimulates the cells of the G2/M phase to apoptosis.Solamargine (72 hours) dramatically inhibits the proliferation of SMMC-7721 and HepG2 cells in a dose- and time-dependent manner. The IC50s are 9.21 and 19.88 μg/ml, respectively. Cell Viability Assay Cell Line:SMMC-7721cells Concentration:15 μg/ml.Incubation Time:72 hours Result:Displayed a significant increase of sub-G1.
体内实验

Solamargine (10 mg/kg; intragastric administration; once daily for 8 days) exhibits an antitumor effect and promotes the apoptosis of GC in vivo. Animal Model:Female specific pathogen-free BALB/c nude mice weighing 18-20 g (6-8-weeks-old) Dosage:10 mg/kg Administration:Intragastric administration; once daily for 8 days Result:Tumor growth was significantly inhibited .
同义词

Solamargin | δ-Solanigrine
通路

Angiogenesis
靶点

PKC
受体

p38 MAPK| STAT3
研究领域

Cancer
适应症

——

CAS Number

20311-51-7
分子量

868.07
分子式

C45H73NO15
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 8.8 mg/mL; 10.14 mM
SMILES

[C@H]1([C@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]1CC2=CC[C@H]3[C@@H]4C[C@@H]5O[C@]6([C@H]([C@@H]5[C@]4(CC[C@@H]3[C@]2(CC1)C)C)C)NC[C@@H](CC6)C)O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)O)O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)CO
化学全称

——

1. Sani IK., et al. Toxicol In Vitro. 2015 Aug;29(5):893-900.

计算器

产品手册

关联产品

PKC β pseudosubstrat...

Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM). Consists of amino acids 19 - 31 of PKC pseudosubstrate domain linked by a disulphide bridge to a cell permeabilisation Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide.
Indolactam V

Indolactam V ((-)-Indolactam V) 是一种吲哚生物碱肿瘤促进剂，可激活蛋白激酶 C (PKC)。
Phorbol 12-myristate...

一种 PKC 激活剂，包括 A 组（α、βI、βII、γ）和 B 组（δ、ε、η、θ）亚型。