Solamargine ( Solamargin | δ-Solanigrine )

产品货号. M17419 CAS No. 20311-51-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Solamargine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Solamargine 是从中药 Solanum nigrum L. (SNL) 中提取的主要甾体生物碱苷；已被证明可以抑制多种癌细胞的生长并诱导其凋亡。
产品描述

Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cells.
体外实验

Solamargine (15 μg/ml; 72 hours) predominantly stimulates the cells of the G2/M phase to apoptosis.Solamargine (72 hours) dramatically inhibits the proliferation of SMMC-7721 and HepG2 cells in a dose- and time-dependent manner. The IC50s are 9.21 and 19.88 μg/ml, respectively. Cell Viability Assay Cell Line:SMMC-7721cells Concentration:15 μg/ml.Incubation Time:72 hours Result:Displayed a significant increase of sub-G1.
体内实验

Solamargine (10 mg/kg; intragastric administration; once daily for 8 days) exhibits an antitumor effect and promotes the apoptosis of GC in vivo. Animal Model:Female specific pathogen-free BALB/c nude mice weighing 18-20 g (6-8-weeks-old) Dosage:10 mg/kg Administration:Intragastric administration; once daily for 8 days Result:Tumor growth was significantly inhibited .
同义词

Solamargin | δ-Solanigrine
通路

Angiogenesis
靶点

PKC
受体

p38 MAPK| STAT3
研究领域

Cancer
适应症

——

CAS Number

20311-51-7
分子量

868.07
分子式

C45H73NO15
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 8.8 mg/mL; 10.14 mM
SMILES

[C@H]1([C@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]1CC2=CC[C@H]3[C@@H]4C[C@@H]5O[C@]6([C@H]([C@@H]5[C@]4(CC[C@@H]3[C@]2(CC1)C)C)C)NC[C@@H](CC6)C)O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)O)O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)CO
化学全称

——

1. Sani IK., et al. Toxicol In Vitro. 2015 Aug;29(5):893-900.

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