Tebanicline ( —— )

产品货号. M17413 CAS No. 198283-73-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Tebanicline
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Tebanicline（ABT-594，Ebanicline）作为神经元烟碱乙酰胆碱受体的部分激动剂，与 α3β4 和 α4β2 亚型结合。
产品描述

Tebanicline (ABT-594, Ebanicline) acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. Tebanicline is an effective synthetic nicotinic (non-opioid) analgesic drug developed by Abbott. It was developed as a less toxic analog of the potent poison dart frog-derived compound epibatidine, which is some 200x stronger than morphine as an analgesic but produces extremely dangerous toxic side effects. Like epibatidine, Tebanicline showed potent analgesic activity against neuropathic pain in both animal and human trials, but with far less toxicity than its parent compound.
体外实验

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体内实验

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同义词

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通路

Cell Cycle/DNA Damage
靶点

PLK
受体

nAChR
研究领域

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适应症

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1. Hayashi T, et al.Neurosci Lett. 2016 Dec 7;638:46-50.

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