BDA 366

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BDA-366 特异性靶向 Bcl2 BDA-366 的 BH4 结构域并抑制人骨髓瘤生长。 BDA-366 通过诱导 BCL2 构象变化，在 MM 细胞系和原代 MM 细胞中诱导强烈的细胞凋亡。

BDA-366 is a BCL2-BH4 antagonist. BDA-366 suppresses human myeloma growth. BDA-366 induces robust apoptosis in MM cell lines and primary MM cells by inducing BCL2 conformational change. Delivery of BDA-366 substantially suppressed the growth of human MM xenografts in NOD-scid/IL2Rγnull mice, without significant cytotoxic effects on normal hematopoietic cells or body weight. Thus, BDA-366 functions as a novel BH4-based BCL2 inhibitor and offers an entirely new tool for MM therapy.

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BDA-366 | BDA 366 | BDA366

Others

Other Targets

Bcl-2-BH4

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1821496-27-8

423.26

C24H29N3O4

>98% (HPLC)

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CCN(CC)C[C@@H](O)CNc1ccc(NC[C@H]2CO2)c2C(=O)c3ccccc3C(=O)c12

1-(((S)-3-(diethylamino)-2-hydroxypropyl)amino)-4-((((S)-oxiran-2-yl)methyl)amino)anthracene-9,10-dione

(-20℃)

With Ice Pack

≥ 2 years