LDC1267 ( LDC1267 | LDC-1267 | LDC 1267 )

产品货号. M17256 CAS No. 1361030-48-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

LDC1267
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

LDC1267 是一种极好的特异性 TAM（Tyro3、Axl 和 Mer）激酶抑制剂，针对 Mer（IC50<5 nM）、Tyro3（IC50=8 nM）和 Axl（IC50=29 nM）。
产品描述

LDC1267 is a potent and selective TAM kinase inhibitor. LDC1267 displays lower activity against Met, Aurora B, Lck, Src, and CDK8. LDC1267 markedly reduced murine mammary cancer and melanoma metastases dependent on NK cells. The TAM tyrosine kinase receptors Tyro3, Axl and Mer (also known as Mertk) were identified as ubiquitylation substrates for Cbl-b. Treatment of wild-type NK cells with a newly developed small molecule TAM kinase inhibitor conferred therapeutic potential, efficiently enhancing anti-metastatic NK cell activity in vivo.
体外实验

——
体内实验

Animal Model:C57BL/6J wild type mice (8-12 weeks old syngeneic bearing B16F10 cells) Dosage:20mg/kg Administration:Intraperitoneal injection; every 12 hours for 14 daysResult:Markedly reduced metastatic spreading of melanomas.
同义词

LDC1267 | LDC-1267 | LDC 1267
通路

Cell Cycle/DNA Damage
靶点

PLK
受体

AXL| Mer| Tyro3
研究领域

Inflammation/Immunology
适应症

——

CAS Number

1361030-48-9
分子量

560.55
分子式

C30H26F2N4O5
纯度

>98% (HPLC)
溶解度

DMSO : 50 mg/mL. 89.20 mM; H2O : < 0.1 mg/mL
SMILES

c1(c(cc2c(c1)c(ccn2)Oc1ccc(cc1F)NC(=O)c1nn(cc1OCC)c1ccc(cc1C)F)OC)OC
化学全称

N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-4-ethoxy-1-(4-fluoro-2-methyl-phenyl)pyrazole-3-carboxamide

1. Paolino M, et al. Nature. 2014, 507(7493), 508-512.

计算器

产品手册

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