NQ301

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NQ301 是一种抗血栓剂，可抑制胶原蛋白挑战的兔血小板聚集（IC50：10 mg/mL）。

NQ-301 is a Selective CD45 inhibitor with Antiplatelet and antithrombotic activities (IC50 = 200 nM). NQ301 inhibits thromboxane A2 receptor and synthase activity in rabbit platelets. The antiplatelet activity of NQ301 may be mediated by inhibition of cytosolic Ca2+ mobilization, enhancement of cAMP production and inhibition of ATP secretion in activated platelets.

NQ301 concentration-dependently inhibits collagen (10 mg/mL)-, U46619 (1 mg/mL)- and arachidonic acid (100 mg/mL)-challenged rabbit platelet aggregation, with IC50values of 0.60±0.02, 0.58±0.04 and 0.78±0.04 μM, respectively. NQ301 potently suppresses thromboxane B2 formation by platelets that are exposed to arachidonic acid in a concentration-dependent manner, but had no effect on the production of prostaglandin D2, indicating an inhibitory effect on thromboxane A2 synthase. NQ301 has a potential to inhibit thromboxane A2 synthase activity with thromboxane A2/prostaglandin H2 receptor blockade, and modulate arachidonic acid liberation as well as 12-hydroxy-5,8,10,14-eicosatetraenoic acid formation in platelets. NQ301 inhibits platelet aggregation by suppression of the intracellular pathway, rather than by direct inhibition of fibrinogen-GPIIb/IIIa complex binding. NQ301 significantly inhibits the increase of cytosolic Ca2+ concentration and ATP secretion, and also significantly increases platelet cAMP levels in the activated platelets. The antiplatelet activity of NQ301 may be mediated by inhibition of cytosolic Ca2+ mobilization, enhancement of cAMP production and inhibition of ATP secretion in activated platelets.

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NQ-301 | NQ 301 | NQ301

Angiogenesis

c-Met/HGFR

arachidonic acid-challenged rabbit platelet aggregation| collagen-challenged rabbit platelet aggregation| U46619-challenged rabbit platelet aggregation

Cardiovascular Disease|Infection

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130089-98-4

325.75

C18H12ClNO3

>98% (HPLC)

DMSO : ≥ 29 mg/mL. 89.03 mM

CC(=O)c1ccc(cc1)NC1=C(C(=O)c2ccccc2C1=O)Cl

2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione

(-20℃)

With Ice Pack

≥ 2 years