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B-Raf inhibitor 1 dihydrochloride
CAS No. 1191385-19-9
B-Raf inhibitor 1 dihydrochloride ( B-Raf inhibitor 1 dihydrochloride )
产品货号. M17180 CAS No. 1191385-19-9
B-Raf 抑制剂 1 是一种有效的选择性 B-Raf 抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥540 | 有现货 |
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| 5MG | ￥1007 | 有现货 |
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| 10MG | ￥1672 | 有现货 |
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| 25MG | ￥2762 | 有现货 |
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| 50MG | ￥4073 | 有现货 |
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| 100MG | ￥5625 | 有现货 |
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| 500MG | ￥11430 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1359 | 有现货 |
|
生物学信息
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产品名称B-Raf inhibitor 1 dihydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述B-Raf 抑制剂 1 是一种有效的选择性 B-Raf 抑制剂。
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产品描述B-Raf inhibitor 1 dihydrochloride is a novel potent and selective B-Raf inhibitor.
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体外实验B-Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC50s of 0.31 and 0.72 μM, respectively. B-Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. B-Raf inhibitor 1 (Compound 13) additionally exhibits low micromolar inhibition against wild type B-Raf cell lines, which may be due to off-target kinase activities or alternatively to pan-Raf inhibition, including Raf dimers.
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体内实验——
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同义词B-Raf inhibitor 1 dihydrochloride
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通路Cytoskeleton/Cell Adhesion Molecules
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靶点Akt
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受体B-Raf
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研究领域Cancer
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适应症——
化学信息
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CAS Number1191385-19-9
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分子量478.94
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分子式C26H19ClN8
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纯度>98% (HPLC)
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溶解度——
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SMILESCc1c(c2c(cc1)c(ncc2)Nc1ccc(cc1)Cl)Nc1c(cccn1)c1c2c(ncn1)nc[nH]2.Cl.Cl
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化学全称1-N-(4-Chlorophenyl)-6-methyl-5-N-[3-(7H-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine dihydrochloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Wang X, et al. J Med Chem. 2012 Sep 13;55(17): 7332-41.
