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UNC 926 hydrochloride
CAS No. 1184136-10-4
UNC 926 hydrochloride ( —— )
产品货号. M17174 CAS No. 1184136-10-4
UNC-926 抑制 L3MBTL1（IC50：3.9 μM）。 UNC-926 还表现出对 L3MBTL3 的低微摩尔亲和力。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥273 | 有现货 |
|
| 10MG | ￥464 | 有现货 |
|
| 25MG | ￥882 | 有现货 |
|
| 50MG | ￥1488 | 有现货 |
|
| 100MG | ￥2115 | 有现货 |
|
| 200MG | ￥3024 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥240 | 有现货 |
|
生物学信息
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产品名称UNC 926 hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述UNC-926 抑制 L3MBTL1（IC50：3.9 μM）。 UNC-926 还表现出对 L3MBTL3 的低微摩尔亲和力。
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产品描述UNC-926 inhibits L3MBTL1 (IC50: 3.9 μM). UNC-926 also exhibits a low micromolar affinity for L3MBTL3. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1. It selectively and dose-dependently inhibits the L3MBTL13xMBT-H4K20me1 interaction. UNC-926 has not an effect on the binding of 53BP1 to H4K20me1.
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体外实验UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7.UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体L3MBTL1
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研究领域Others-Field
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适应症——
化学信息
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CAS Number1184136-10-4
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分子量373.72
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分子式C16H21BrN2O·HCl
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 41.67 mg/mL (123.56 mM)
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SMILESC1CCN(C1)C1CCN(CC1)C(=O)c1cc(ccc1)Br
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Herold JM, et al. Structure–activity relationships of methyl-lysine reader antagonists. MedChemComm. 2012;3(45):45–51.
产品手册
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