VU 0361737 ( VU 0361737, VU-0361737, VU0361737 )

产品货号. M17159 CAS No. 1161205-04-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

VU 0361737
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

VU 0361737 是 mGlu4 受体的特异性正变构调节剂 (PAM)。VU 0361737 对于人类受体的 EC50 为 240 nM。
产品描述

VU 0361737 is a selective positive allosteric modulator at mGluR-4 (EC50 values are 240 and 110 nM at human and rat receptors respectively).
体外实验

VU0361737 displays weak activity at mGlu5 and mGlu8 receptors and inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors.VU0361737 (1-10 μM) partially attenuates the Staurosporine (HY-15141)- and Doxorubicin (HY-15142)-evoked cell death on human neuroblastoma SH-SY5Y cells.
体内实验

VU0361737 exhibits terminal elimination half-lives (rat 1.9 h) due to high plasma clearance (894 mL/min/kg) following Intraperitoneal injection ( rat 10 mg/kg). Animal Model:Male Sprague-Dawley rats (225-250 g)Dosage:10 mg/kg (Pharmacokinetic Analysis)Administration:Intraperitoneal injection Result:T1/2 (1.9 h).
同义词

VU 0361737, VU-0361737, VU0361737
通路

Others
靶点

Other Targets
受体

mGluR4 (Human)| mGluR4 (Rat )
研究领域

Neurological Disease
适应症

——

1. Engers DW, et al. J Med Chem, 2009, 52(14), 4115-4118.

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